Development of new drugs and new pharmacotherapeutic approaches for the treatment of human and animal pathologies

The physicochemical and pharmacological limitations presented by commonly used drugs have directed the research for structural analogues and for new molecular targets able to function as alternative mechanisms of action, which may increase the therapeutic efficacy of those molecules. Those new approaches involve concepts related to Bioinformatics and Pharmaceutical Technology and have revolutionized several areas of Medicine. In this context, it is worth noting the studies on Molecular Modelling and Dynamics, where molecular structures are simulated, and interactions between drugs and their molecular targets are analyzed, to create new drug candidate molecules. Another important strategy described to overcome traditional biopharmaceutical approaches used in clinical practice involves using and developing new drug delivery systems or nanocarriers.
Towards integrating these two aspects, this research proposal aims to design new molecules and to improve pharmacotherapeutic approaches, as well as to evaluate their application for treatment several human and veterinary pathologies. Specific aims are: (i) studies of modelling / molecular dynamics, protein-protein docking and virtual screening for the development of new allosteric inhibitors and identification of their therapeutic targets; (ii) studies of the influence of coating with proteins on the stability and conductivity of silver nanoparticles; (iii) biogenic synthesis and development of silver (nitric oxide donors) and copper nanoparticles for biomedical, environmental and agricultural applications; (iv) development and pharmacological evaluation of thermosensitive hydrogels as drug nanocarriers systems. In this research proposal participates researchers associated with the Nanomedicine Research Unit, characterizing its high potential for technological innovation.

Coordinator: Prof. Dr. Sérgio Daishi Sasaki
E-mail: sergio.sasaki@ufabc.edu.br

Coordinator’s Curriculum Lattes (research projects, publications and academic info)

Coordinator’s research grants, scholarships and main publications (FAPESP)

Development of new drugs and new pharmacotherapeutic approaches for the treatment of human and animal pathologies

The physicochemical and pharmacological limitations presented by commonly used drugs have directed the research for structural analogues and for new molecular targets able to function as alternative mechanisms of action, which may increase the therapeutic efficacy of those molecules. Those new approaches involve concepts related to Bioinformatics and Pharmaceutical Technology and have revolutionized several areas of Medicine. In this context, it is worth noting the studies on Molecular Modelling and Dynamics, where molecular structures are simulated, and interactions between drugs and their molecular targets are analyzed, to create new drug candidate molecules. Another important strategy described to overcome traditional biopharmaceutical approaches used in clinical practice involves using and developing new drug delivery systems or nanocarriers.
Towards integrating these two aspects, this research proposal aims to design new molecules and to improve pharmacotherapeutic approaches, as well as to evaluate their application for treatment several human and veterinary pathologies. Specific aims are: (i) studies of modelling / molecular dynamics, protein-protein docking and virtual screening for the development of new allosteric inhibitors and identification of their therapeutic targets; (ii) studies of the influence of coating with proteins on the stability and conductivity of silver nanoparticles; (iii) biogenic synthesis and development of silver (nitric oxide donors) and copper nanoparticles for biomedical, environmental and agricultural applications; (iv) development and pharmacological evaluation of thermosensitive hydrogels as drug nanocarriers systems. In this research proposal participates researchers associated with the Nanomedicine Research Unit, characterizing its high potential for technological innovation.

Coordinator: Prof. Dr. Sérgio Daishi Sasaki
E-mail: sergio.sasaki@ufabc.edu.br

Coordinator’s Curriculum Lattes (research projects, publications and academic info)

Coordinator’s research grants, scholarships and main publications (FAPESP)